The influence of infection on cytokine gene polymorphisms in evolution

Scott, Rodney; Moscovis, Sophia; Hall, Sharron; Gleeson, Maree; Roberts-Thomson, June; Blackwell, C

doi:https://doi.org/10.3828/bfarm.2006.2.1

Before Farming (2006), 2006, (2), 1–7.

DOI: https://doi.org/10.3828/bfarm.2006.2.1
Language: English
Pages: 7

Abstract

Diverse populations appear to harbour different susceptibilities to disease and this has often been associated with poor socio-economic status. Since the completion of the human genome project new findings are beginning to challenge the notion that environmental pressures are the most significant in terms of health and disease. Evidence is accumulating that suggests genetic factors contribute in tandem with socio-economic status to health and disease not only at the individual but also at the population level.

By studying cytokine polymorphisms it is possible to define, to some extent, the relationship between a host population and disease. The relationship between disease evolution and a populations' response is dynamic and ever changing. In this report we have examined the incidence of a series of cytokine polymorphisms in three different populations that hail from three different parts of the world. The cytokine profiles of the three populations are distinct and probably reflect the pathogenic influence each population was exposed to in the distant past.

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