The influence of infection on cytokine gene polymorphisms in evolution

Before Farming (2006), 2006, (2), 1–7.

DOI: https://doi.org/10.3828/bfarm.2006.2.1
Language: English
Pages: 7

Abstract

Diverse populations appear to harbour different susceptibilities to disease and this has often been associated with poor socio-economic status. Since the completion of the human genome project new findings are beginning to challenge the notion that environmental pressures are the most significant in terms of health and disease. Evidence is accumulating that suggests genetic factors contribute in tandem with socio-economic status to health and disease not only at the individual but also at the population level.

By studying cytokine polymorphisms it is possible to define, to some extent, the relationship between a host population and disease. The relationship between disease evolution and a populations' response is dynamic and ever changing. In this report we have examined the incidence of a series of cytokine polymorphisms in three different populations that hail from three different parts of the world. The cytokine profiles of the three populations are distinct and probably reflect the pathogenic influence each population was exposed to in the distant past.

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Alessandri, LM, Read, AW, Stanley, FJ, Burton, PR & Dawes VP 1994. Sudden infant death syndrome in aboriginal and non-aboriginal infants. Journal of Paediatrics and Child Health 30:234-241. Sudden infant death syndrome in aboriginal and non-aboriginal infants Journal of Paediatrics and Child Health 30 234 241 Google Scholar

Allesandri, LM, Chambers, HM, Blair, EM & Read, AW 2001. Perinatal and postneonatal mortality among Indigenous and non-Indigenous infants born in Western Australia. Medical Journal of Australia 175:185-189. Perinatal and postneonatal mortality among Indigenous and non-Indigenous infants born in Western Australia Medical Journal of Australia 175 185 189 Google Scholar

Google Scholar

Blackwell, CC, Moscovis, SM, Gordon, AE, Al Madani, OM, Gleeson, M, Scott, RJ, Hall, ST, Weir, DM & Busuttil, A 2004. Ethnicity, Infection and Sudden Infant Death Syndrome. FEMS Immunology and Medical Microbiology 42:53-65. Ethnicity, Infection and Sudden Infant Death Syndrome FEMS Immunology and Medical Microbiology 42 53 65 Google Scholar

Boehmke, F, Esnaashari, H, Seitzer, U, Kothe, H Maass, M, Zabel, P & Dalhoff K 2003. Pneumococcal septic shock is associated with the interleukin-10-1082 gene promotor polymorphism. American Journal of Respiratory and Critical Care Medicine 168:476-480. Pneumococcal septic shock is associated with the interleukin-10-1082 gene promotor polymorphism American Journal of Respiratory and Critical Care Medicine 168 476 480 Google Scholar

Currie, BJ & Brewster, DR 2001. Childhood infections in the tropical north of Australia. Journal of Paediatrics and Child Health 37:326-330. Childhood infections in the tropical north of Australia Journal of Paediatrics and Child Health 37 326 330 Google Scholar

Diamond, J 1997. Guns, Germs and Steel. London: Vintage Random House. Guns, Germs and Steel Google Scholar

El Ahmer, OR, Essery, SD, Saadi, AT Raza, MW, Ogilvie, MM, Weir, DM, & Blackwell, CC 1999a. The effect of cigarette smoke on adherence of respiratory pathogens to buccal epithelial cells. FEMS Immunology and Medical Microbiology 23:27-36. The effect of cigarette smoke on adherence of respiratory pathogens to buccal epithelial cells FEMS Immunology and Medical Microbiology 23 27 36 Google Scholar

Gallagher, PM, Lowe, G, Fitzgerald, T, Bella, A, Greene, CM, McElvaney, NG & O'Neill, SJ 2003. Association of IL-10 polymorphism with severity of illness in community acquired pneumonia. Thorax 58:154-156. Association of IL-10 polymorphism with severity of illness in community acquired pneumonia Thorax 58 154 156 Google Scholar

Girndt, M, Sester, U, Sester, M, Deman, E, Ulrich, C, Kaul, H, Kohler, H 2001. The interleukin-10 promoter genotype determines clinical immune function in hemodialysis patients. Kidney International 60:2385-2391. The interleukin-10 promoter genotype determines clinical immune function in hemodialysis patients Kidney International 60 2385 2391 Google Scholar

Hajeer, AH, Lazarus, M, Turner, D, Mageed, RA, Vencovsky, J, Sinnott, P, Hutchinson, IV, Ollier, WE 1998. IL-10 gene promotor polymorphisms in rheumatoid arthritis. Scandinavian ournal of Rheumatology 27:142-145. IL-10 gene promotor polymorphisms in rheumatoid arthritis Scandinavian ournal of Rheumatology 27 142 145 Google Scholar

Helminen, M, Lahdenpohja, N, Hurme, M 1999. Polymorphism of the interleukin-10 gene is associated with susceptibility to Epstein-Barr virus infection. Journal of Infectious Diseases. 180:496-499. Polymorphism of the interleukin-10 gene is associated with susceptibility to Epstein-Barr virus infection Journal of Infectious Diseases. 180 496 499 Google Scholar

Maizels, RM, Balic, A, Gomez-Excobar N, Nair M, Taylor, MD & Allen JE 2004. Helminth parasites - masters of regulation. Immunological Review 201:89-116. Helminth parasites - masters of regulation Immunological Review 201 89 116 Google Scholar

Meenagh, A, Williams, F, Ross, OA, Patterson, C, Gorodezky, C, Hammond, M, Leheny, WA & Middleton, D 2002. Frequency of cytokine polymorphisms in populations from western Europe, Africa, Asia, the Middle East and South America. Human Immunology 63:1055-1061. Frequency of cytokine polymorphisms in populations from western Europe, Africa, Asia, the Middle East and South America Human Immunology 63 1055 1061 Google Scholar

Moscovis, SM, Gordon, AE, Al Madani, OM, Gleeson, M, Scott, RJ, Hall, ST, Weir, DM, Busuttil, A & Blackwell, CC 2004a. Interleukin-10 and Sudden Infant Death Syndrome. FEMS Immunology and Medical Microbiology 42:130-138. Interleukin-10 and Sudden Infant Death Syndrome FEMS Immunology and Medical Microbiology 42 130 138 Google Scholar

Moscovis, SM, Gordon, AE, Al Madani, OM, Gleeson, M, Scott, RJ, Hall, ST, Weir, DM, Busuttil, A & Blackwell, CC 2004b. Interleukin-1β and Sudden Infant Death Syndrome. FEMS Immunology and Medical Microbiology 42:139-145. Interleukin-1β and Sudden Infant Death Syndrome FEMS Immunology and Medical Microbiology 42 139 145 Google Scholar

Pyo, C-W, Hur, S-S, Kim, Y-K, Choi, H-B, Hong, Y-S, Kim, D-W, Kim, C-C, Kim, H-K & Kim, T-G 2003. Polymorphisms of IL-1β, IL1RN, IL-2, IL-4, IL-6, IL-10 and IFN-γ genes in the Korean population. Human Immunology 64:979-989. Polymorphisms of IL-1β, IL1RN, IL-2, IL-4, IL-6, IL-10 and IFN-γ genes in the Korean population Human Immunology 64 979 989 Google Scholar

Raza, MW & Blackwell, CC 1999. Sudden infant death syndrome: virus infections and cytokines. FEMS Immunology and Medical Microbiology 25:85-96. Sudden infant death syndrome: virus infections and cytokines FEMS Immunology and Medical Microbiology 25 85 96 Google Scholar

Read, RC, Camp, NJ, di Giovine, FS, Borrow, R, Kaczmarski, EB, Chaudhary, AGA, Fox, AJ & Duff, GW 2000. An interleukin-1 genotype is associated with fatal outcome of meningococcal disease. Journal of Infectious Disease 182:1557-1560. An interleukin-1 genotype is associated with fatal outcome of meningococcal disease Journal of Infectious Disease 182 1557 1560 Google Scholar

Santilla, S, Savinainen, K & Hurme, M 1998. Presence of the IL-1RA allele 2 (IL1RN*2) is associated with enhanced IL-1[beta] production in vitro. Scandinavian Journal of Immunology 47:195-198. Presence of the IL-1RA allele 2 (IL1RN*2) is associated with enhanced IL-1[beta] production in vitro Scandinavian Journal of Immunology 47 195 198 Google Scholar

Schaaf, BM, Boehmke, F, Esnaashari, H, Seitzer, U, Kothe, H, Maass, M, Zabel, P, Dalhoff, K 2003. Pneumococcal septic shock is associated with the interleukin-10-1082 gene promoter polymorphism. American Journal of Respiratory and Critical Care Medicine 168:476-480. Pneumococcal septic shock is associated with the interleukin-10-1082 gene promoter polymorphism American Journal of Respiratory and Critical Care Medicine 168 476 480 Google Scholar

Turner, DM, Williams, DM, Sankaran, D, Lazarus, M, Sinnott, PJ, Hutchinson, IV 1997. An investigation of polymorphism in the interleukin-10 gene promoter. European Journal of Immunogenetics 24:1-8. An investigation of polymorphism in the interleukin-10 gene promoter European Journal of Immunogenetics 24 1 8 Google Scholar

Westendorp, RGJ, Langemans, JAM, Huizinga, TWJ, Elouali AH, Verweij, CL, Boomsma, DI & Vandenbrouke, JP 1997. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 349:170-173. Genetic influence on cytokine production and fatal meningococcal disease Lancet 349 170 173 Google Scholar

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